SrasV1, Main, Exploration, bibRecord, 005B21

In vitro inhibition of SARS virus replication by human interferons

Identifieur interne : 005B21 ( Main/Exploration ); précédent : 005B20; suivant : 005B22

In vitro inhibition of SARS virus replication by human interferons

Auteurs : Helena Dahl [Suède] ; Annika Linde [Suède] ; Örjan Strannegard [Suède]

Source :

Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2004.

RBID : Pascal:05-0060697

Descripteurs français

KwdFr :
- Animaux, Antiviraux (pharmacologie), Cellules Vero, Humains, Interféron alpha (pharmacologie), Interféron bêta (pharmacologie), Protéines recombinantes, Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- pharmacologie : Antiviraux, Interféron alpha, Interféron bêta.
- physiologie : Virus du SRAS.
Pascal (Inist)
- Animaux, Cellules Vero, Humains, Protéines recombinantes, Réplication virale, Syndrome respiratoire aigu sévère, Interféron, In vitro, Réplication, Homme, Virus, Virus du SRAS.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animals, Antiviral Agents (pharmacology), Chlorocebus aethiops, Human, Humans, In vitro, Interferon, Interferon alpha-2, Interferon-alpha (pharmacology), Interferon-beta (pharmacology), Recombinant Proteins, Replication, SARS Virus (drug effects), SARS Virus (physiology), Severe acute respiratory syndrome, Vero Cells, Virus, Virus Replication (drug effects).
MESH :
- chemical , pharmacology : Antiviral Agents, Interferon-alpha, Interferon-beta.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Interferon alpha-2, Recombinant Proteins, Vero Cells.

Abstract

Four different types of human interferon, interferon-β (IFN-β), recombinant IFN-α2a and IFN-a2b and natural IFN-α were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-β was found to be the most highly active antiviral agent, followed by natural IFN-a, whereas the 2 recombinant IFN-a2 species were poorly active in the system used. These results suggest that IFN-β as well as natural IFN-a may be used for the treatment of SARS.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Four different types of human interferon, interferon-β (IFN-β), recombinant IFN-α2a and IFN-a2b and natural IFN-α were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-β was found to be the most highly active antiviral agent, followed by natural IFN-a, whereas the 2 recombinant IFN-a2 species were poorly active in the system used. These results suggest that IFN-β as well as natural IFN-a may be used for the treatment of SARS.</div>
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In vitro inhibition of SARS virus replication by human interferons

In vitro inhibition of SARS virus replication by human interferons

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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